OMICS-BASED BIOMARKERS: CURRENT STATUS AND POTENTIAL USE IN THE CLINIC


Simple and sensitive high performance liquid chromatographic method for the simultaneous quantitation of the phenylalanine in human plasma

Phenylalanine (Phe) is the most reliable indicator for the diagnosis of phenylketonuria (PKU).The purpose of this study is to establish a reliable and quick method for the assignment of Phe in peripheral capillary blood from newborns and children by high performance liquid chromatography with ultraviolet detection (HPLC-UV).PKU is an inborn error o

read more

TetR-family transcription factors in Gram-negative bacteria: conservation, variation and implications for efflux-mediated antimicrobial resistance

Abstract Background TetR-family transcriptional regulators (TFTRs) are DNA binding factors that regulate Baby Gift Set gene expression in bacteria.Well-studied TFTRs, such as AcrR, which regulates efflux pump expression, are usually encoded alongside target operons.Recently, it has emerged that there are many TFTRs which act as global multi-target

read more